Fig. 7
- ID
- ZDB-FIG-210510-31
- Publication
- Zhang et al., 2020 - Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module
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Inhibition of BMP signaling with DMH1 reduces injury‐induced id1 and id1‐CRM2:GFP transgene expression. ISH against id1 (A, B) and gfp mRNA (D, E) showed reduction in induction of id1 (B) and gfp (E) transgenes upon BMP signaling inhibition by DMH1 treatment (B and E) in comparison to DMSO‐treated corresponding controls (A and D). Arrowheads indicate upregulation of gene expression the left telencephalic hemisphere upon stab injury. C, F, RT‐qPCR quantification confirmed reduction in id1 and gfp expression in DMH1 treated fish. The data represent the mean ± SD of three independent experiments. Significance is indicated by asterisks:**.001 ≤ P < .01; ***P < .001. Scale bar = 200 μm (A, B, D, and E). n = 3 animals for C, F |