FIGURE

Figure 4

ID

ZDB-FIG-210301-37

Publication

Yao et al., 2021 - Pathways Regulating Establishment and Maintenance of Cardiac Chamber Identity in Zebrafish

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Figure 4

nkx genes are required for maintenance of ventricular cardiomyocyte identity. Compared to the wild-type heart at 52 hpf (A), nkx2.5 mutants (B) exhibit a reduced ventricle and an enlarged atrium, with ectopic Amhc in some ventricular cells (arrows), and additional loss of a single allele of nkx2.7 (C) leads to increased presence of ectopic Amhc in the ventricle (arrows). nkx2.5;nkx2.7 double homozygotes (D) exhibit only a small ventricular remnant, with Amhc present throughout (arrow). Red fluorescence labels sarcomeric myosin heavy chain, and green fluorescence indicates localization of Amhc. Images adapted from [29].

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Cardiovasc Dev Dis