FIGURE

Figure 6

ID

ZDB-FIG-210215-51

Publication

Geusz et al., 2021 - Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

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Figure 6

Laminin and Crb are expressed in zebrafish pancreas progenitors.

(A,B) Confocal images of 36 hr post fertilization (hpf) Tg(ptf1a:eGFP)^jh1 zebrafish foregut endoderm labeled with DAPI (nuclei, grey) and antibodies against Nkx6.1 (blue; pancreatic progenitors) and Laminin (A, red) or panCrb (B, red); n = 10 embryos stained. (A–A”’’) Z-focal plane image showing pancreatic progenitor cells marked by Nkx6.1 (blue) and low level ptf1a:eGFP, labeled with anti-Laminin antibodies (red). (B–B”’’) Pancreatic progenitors labeled with anti-panCrb antibodies (red). Scale bar, 20 µM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	jh1Tg + MO2-lama1 jh1Tg + MO2-crb2a + MO2-crb2b jh1Tg + MO2-crb2a + MO2-crb2b + MO2-lama1
Knockdown Reagents:	MO2-crb2a MO2-crb2b MO2-lama1
Observed In:	intestine pancreas pancreas cell migration pancreas morphogenesis pancreatic acinar gland pancreatic B cell type B pancreatic cell development
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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