Fig 8

(A) Schematic representation of motifs 1, 2, or 3 enrichment in the myelin transcriptome in comparison to length-matched, randomized sequences using MEME suite Analysis of Motif Enrichment (version 5.1.1) [59]. (B) FIMO (version 5.1.1) was used to determine the frequency at which motif 2 is present in the myelin transcriptome [60]. cDNA sequences from the myelin transcriptome were analyzed for the presence of motif 2. One or more copies of motif 2 were present in 42.4% of myelin cDNAs. (C) FIMO was used to determine the frequency at which motif 2 is present in the mouse transcriptome. cDNA sequences from the mouse annotated genome (mm10) were analyzed for the presence of motif 2. One or more copies of motif 2 were present in 28.7% of mouse cDNAs. (D) Percentage of motif 2 occurrences in 5′ UTR, coding sequences, 3′ UTR or other positions in myelin transcriptome. Motifs in the “other” category represent motifs overlapping 2 regions. (E) Top 20 GO terms identified in the myelin transcriptome. (F) Top 20 GO terms identified in myelin transcripts containing motif 2. Terms are ordered from most to least significant based on -log2 of the false discovery rates. Counts represent number of genes identified with the GO term. The underlying numerical data can be found in S8–S10 Data. FIMO, Find Individual Motif Occurrences; GO, gene ontology; MEME, Multiple Em for Motif Elicitation; UTR, untranslated region.