FIGURE

Figure 7

ID
ZDB-FIG-210123-18
Publication
Helal et al., 2021 - Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model
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Figure 7

Proposed model for interaction between oncogenic hepatocytes and cholangiocytes in the kras + transgenic zebrafish model. First, oncogenic hepatocytes after krasv12 activation promote accumulation of triglycerides and elevate secretion of bile acids. Second, bile acids induce cholangiocyte proliferation through S1pr2, which, upon activation, induces pERK and secretion of Il17a/f1 cytokine. Third, Il17a/f1 binds to its receptor Il17ra1a on hepatocytes and promotes tumorigenesis through an inflammation pathway.
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