ZFIN Image: Helal et al., 2021, Figure 7

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Figure Caption

Figure 7

Proposed model for interaction between oncogenic hepatocytes and cholangiocytes in the kras + transgenic zebrafish model. First, oncogenic hepatocytes after kras^v12 activation promote accumulation of triglycerides and elevate secretion of bile acids. Second, bile acids induce cholangiocyte proliferation through S1pr2, which, upon activation, induces pERK and secretion of Il17a/f1 cytokine. Third, Il17a/f1 binds to its receptor Il17ra1a on hepatocytes and promotes tumorigenesis through an inflammation pathway.

Acknowledgments

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