FIGURE

Fig. 7

ID

ZDB-FIG-201026-23

Publication

Choi et al., 2020 - Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis

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Fig. 7

Hypothetical schematic diagram: abnormal promotion of PP1 activity in the MNs of ALS and dephosphorylation of the S616 site of Drp1, resulting in the induction of mitochondrial fragmentation.

Also, abnormal PP1 activity decreases the mitochondrial complex I activity, leading to axonal degeneration. Thus, the blockade of PP1 activity reduces the ALS-induced mitochondrial fission and improves mitochondrial functions such as the complex I activity of the mitochondrial electron transport chain and membrane potential, resulting in improvement of axonal impairment. Therefore, inhibition of excessive PP1 activity may promote MN survival by improving mitochondrial function.

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