ZFIN Image: Choi et al., 2020, Fig. 7

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Figure Caption

Fig. 7 Hypothetical schematic diagram: abnormal promotion of PP1 activity in the MNs of ALS and dephosphorylation of the S616 site of Drp1, resulting in the induction of mitochondrial fragmentation.

Also, abnormal PP1 activity decreases the mitochondrial complex I activity, leading to axonal degeneration. Thus, the blockade of PP1 activity reduces the ALS-induced mitochondrial fission and improves mitochondrial functions such as the complex I activity of the mitochondrial electron transport chain and membrane potential, resulting in improvement of axonal impairment. Therefore, inhibition of excessive PP1 activity may promote MN survival by improving mitochondrial function.

Acknowledgments

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