FIGURE

Figure 1

ID

ZDB-FIG-200824-8

Publication

Ito et al., 2020 - Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor

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Figure 1

Bath application of strychnine, picrotoxin, nifedipine or niflumic acid to zebrafish embryos at 48 hpf caused abnormal touch response touch. (a) A superimposed image of 100 Hz movie frames. A control wild-type embryo (1% DMSO) responded to tactile stimulation and showed swimming by side-to-side trunk contractions. (b) Strychnine-treated embryos responded to touch by bilateral muscle contractions that resulted in shortening of the body along anterior–posterior axis. (c) Picrotoxin-treated embryos exhibited similar shrinkage of the body. (d) Nifedipine-treated embryos showed similar abnormal touch response. (e) Niflumic acid-treated embryos also responded to touch by bilateral muscle contractions.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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