FIGURE

Figure 4

ID

ZDB-FIG-200824-11

Publication

Ito et al., 2020 - Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor

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Figure 4

Drug-mediated inhibition of homomeric and heteromeric human GlyRs. (a) A recording from a hGlyRα1-injected oocyte exposed to 200 µM glycine with increasing amounts of niflumic acid. (b) Cumulative concentration-dependent inhibition of GlyRα1 current by strychnine, picrotoxin, nifedipine and niflumic acid (n = 10 each). (c) A recording from an oocyte, which were injected with hGlyRα1 and hGlyRβ and exposed to 200 µM glycine and increasing amounts of niflumic acid. (d) Cumulative concentration-curves of strychnine, picrotoxin, nifedipine and niflumic acid-mediated inhibition of α1/β heteromeric human GlyRs (n = 10 each).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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