ZFIN Figure: Rödel et al., 2019, Fig. 1

ZFIN ID: ZDB-FIG-200618-17

ZFIN ID: ZDB-FIG-200618-17

Rödel et al., 2019 - Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. Circulation research 125(10):e43-e54 Full text @ Circ. Res.

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Antibody:	Ab1-cdh5
Fish:	WT krit1^{ty219c/ty219c} krit1^{ty219c/ty219c}; md40Tg/+; ubs3Tg/+
Anatomical Term:	lateral dorsal aorta cell surface
Stage:	Long-pec

PHENOTYPE:

Fish:	krit1^{ty219c/ty219c} s843Tg + MO1-tnnt2a krit1^{ty219c/ty219c}; md40Tg/+; s843Tg; ubs3Tg/+ krit1^{ty219c/ty219c}; md40Tg/+; ubs3Tg/+ krit1^{ty219c/ty219c}; s843Tg
Knockdown Reagent:	MO1-tnnt2a
Observed In:	caudal vein plexus dorsal aorta dorsal aorta endothelial cell heart intersegmental vessel lateral dorsal aorta lateral dorsal aorta endothelial cell
Stage:	Long-pec

Fig. 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available

Antibody Labeling Details

Antibody	Assay	Fish	Conditions	Stage	Anatomy
Ab1-cdh5	IHC	WT	control	Long-pec	lateral dorsal aorta cell surface
	IHC	krit1^{ty219c/ty219c}	control	Long-pec	lateral dorsal aorta cell surface
	IHC	krit1^{ty219c/ty219c}; md40Tg/+; ubs3Tg/+	control	Long-pec	lateral dorsal aorta cell surface

Phenotype Details

Fish	Conditions	Stage	Phenotype
krit1^{ty219c/ty219c}	control	Long-pec	lateral dorsal aorta endothelial cell elongated, abnormal
		Long-pec	lateral dorsal aorta endothelial cell increased area, abnormal
krit1^{ty219c/ty219c}; md40Tg/+; s843Tg; ubs3Tg/+	control	Long-pec	dorsal aorta endothelial cell amount, ameliorated
		Long-pec	dorsal aorta morphology, ameliorated
		Long-pec	lateral dorsal aorta morphology, ameliorated
krit1^{ty219c/ty219c}; md40Tg/+; ubs3Tg/+	control	Long-pec	lateral dorsal aorta endothelial cell increased area, abnormal
		Long-pec	lateral dorsal aorta endothelial cell shape, ameliorated
krit1^{ty219c/ty219c}; s843Tg	control	Long-pec	caudal vein plexus morphology, abnormal
		Long-pec	dorsal aorta dilated, abnormal
		Long-pec	dorsal aorta endothelial cell increased amount, abnormal
		Long-pec	heart morphology, abnormal
		Long-pec	intersegmental vessel morphology, abnormal
		Long-pec	lateral dorsal aorta dilated, abnormal
		Long-pec	lateral dorsal aorta endothelial cell elongated, abnormal
		Long-pec	lateral dorsal aorta endothelial cell increased amount, abnormal
		Long-pec	lateral dorsal aorta endothelial cell increased area, abnormal
s843Tg + MO1-tnnt2a	control	Long-pec	caudal vein plexus morphology, abnormal
		Long-pec	intersegmental vessel morphology, abnormal
		Long-pec	lateral dorsal aorta morphology, abnormal

Full text @ Circ. Res.