FIGURE

Fig. 1.

ID

ZDB-FIG-200608-22

Publication

Cigliola et al., 2020 - Building bridges, not walls: spinal cord regeneration in zebrafish

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Fig. 1.

Different responses to spinal cord injury (SCI) in zebrafish and mammals. Representation of different cellular events occurring after SCI in zebrafish and mice. Upon SCI in mammals, a complex cascade of events occurs, leading to the formation of a scar at the lesion site constructed by stromal-derived fibroblasts, inflammatory immune cells and hypertrophic astrocytes. The scar impedes the regrowth of spared axons. Conversely, in zebrafish, injury induces the infiltration of immune cells followed by bridging of glial cells and axonal tracts, leading to functional regeneration.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.