ZFIN ID: ZDB-PUB-200529-2
Building bridges, not walls: spinal cord regeneration in zebrafish
Cigliola, V., Becker, C.J., Poss, K.D.
Date: 2020
Source: Disease models & mechanisms   13(5): (Review)
Registered Authors: Cigliola, Valentina, Poss, Kenneth D.
Keywords: Regeneration, Spinal cord, Zebrafish
MeSH Terms:
  • Animals
  • Neovascularization, Physiologic
  • Neural Stem Cells/cytology
  • Neurons/cytology
  • Signal Transduction
  • Spinal Cord Regeneration/physiology*
  • Zebrafish/physiology*
PubMed: 32461216 Full text @ Dis. Model. Mech.
Spinal cord injury is a devastating condition in which massive cell death and disruption of neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals, spinal cord tissue has minimal capacity to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of spinal cord regeneration in zebrafish. We highlight recent progress as well as areas requiring emphasis in a line of study that has great potential to uncover strategies for human spinal cord repair.