PUBLICATION

Building bridges, not walls: spinal cord regeneration in zebrafish

Authors
Cigliola, V., Becker, C.J., Poss, K.D.
ID
ZDB-PUB-200529-2
Date
2020
Source
Disease models & mechanisms   13(5): (Review)
Registered Authors
Cigliola, Valentina, Poss, Kenneth D.
Keywords
Regeneration, Spinal cord, Zebrafish
MeSH Terms
  • Animals
  • Neovascularization, Physiologic
  • Neural Stem Cells/cytology
  • Neurons/cytology
  • Signal Transduction
  • Spinal Cord Regeneration/physiology*
  • Zebrafish/physiology*
PubMed
32461216 Full text @ Dis. Model. Mech.
Abstract
Spinal cord injury is a devastating condition in which massive cell death and disruption of neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals, spinal cord tissue has minimal capacity to regenerate after injury. In stark contrast, the regeneration of a completely transected spinal cord and accompanying reversal of paralysis in adult zebrafish is arguably one of the most spectacular biological phenomena in nature. Here, we review reports from the last decade that dissect the mechanisms of spinal cord regeneration in zebrafish. We highlight recent progress as well as areas requiring emphasis in a line of study that has great potential to uncover strategies for human spinal cord repair.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping