ZFIN Image: Cigliola et al., 2020, Fig. 1.

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Figure Caption

Fig. 1.

Different responses to spinal cord injury (SCI) in zebrafish and mammals. Representation of different cellular events occurring after SCI in zebrafish and mice. Upon SCI in mammals, a complex cascade of events occurs, leading to the formation of a scar at the lesion site constructed by stromal-derived fibroblasts, inflammatory immune cells and hypertrophic astrocytes. The scar impedes the regrowth of spared axons. Conversely, in zebrafish, injury induces the infiltration of immune cells followed by bridging of glial cells and axonal tracts, leading to functional regeneration.

Acknowledgments

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