FIGURE

Fig. 3

ID

ZDB-FIG-200416-2

Publication

Wu et al., 2020 - Disruption of dmrt1 rescues the all-male phenotype of cyp19a1a mutant in zebrafish - A Novel insight into the roles of aromatase/estrogens in gonadal differentiation and early folliculogenesis

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Fig. 3

Estrogen suppression of dmrt1 expression. (A) The reciprocal expression of dmrt1 and cyp19a1a in wild-type individuals at 15 dpf (n=7). (B) Expression of dmrt1 in cyp19a1a+/− (n=15) and cyp19a1a−/− (n=5) zebrafish at 25 dpf. Individual data points are shown. (C) Response of dmrt1 expression to E2 treatment (0 nM, 1.21±0.86, n=4; 0.5 nM, 0.33±0.14, n=6; 5 nM, 0.28±0.19, n=6) at 4 mpf. The data points are expressed as mean±s.d. and the exact values are shown under the x-axis. Statistical significance was revealed by one-way ANOVA and Tukey's test (*P<0.05). (D) Histology of representative fish exposed to different concentrations of E2 (0 nM, 0.5 nM and 5 nM).

Expression Data

Genes:	cyp19a1a dmrt1
Fish:	AB cyp19a1a^umo5/umo5 (AB)
Anatomical Term:	immature gonad
Stage Range:	Days 14-20 to Days 21-29

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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