FIGURE

Fig. 3

ID

ZDB-FIG-191014-11

Publication

Wang et al., 2019 - Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1

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Fig. 3

20-HETE or PGE₂ partly reverses the antiangiogenic activities of isoliquiritigenin (ISL) in the rabbit cornea. A 7–0 black silk was used to pass the rabbit corneal stroma 1 mm from the horizontal to the limbus with a length of 3 mm to induce corneal neovascularization model. One week after suturing, the suture was removed, and the flavonoid ISL (1 and 2 mg/ml), ISL (2 mg/ml) plus 20-HETE or PGE₂, and vehicle were performed twice a day for a week in eye drops. Photographs were taken with a stereomicroscope at day 0, 3 and 7 after treatment (a), and the vessel areas were quantified using image pro plus 6.0 (b). The values are presented as the mean ± SEM, n = 6. ^*P < 0.05; ^**P < 0.01 vs. control; ^#P < 0.05; ^##P < 0.01 vs. ISL or GLA-treated groups

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.