FIGURE

Fig. 5

ID

ZDB-FIG-190730-29

Publication

Garland et al., 2019 - Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration

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Fig. 5

Partial antisense repression of Cripto-1 rescues inhibition of regeneration by BDP. a) Translation-blocking cripto-1 morpholino oligo (MO) transiently knocked down Cripto-1. The morphants developed the characteristic one-eyed pinhead phenotype by 2 days post-fertilization (dpf). b) The control and cripto-1morphants were exposed to DMSO or beclomethasone dipropionate (BDP) at 2 dpf following amputation. The dotted lines mark the plane of amputation. Regenerative progression was evaluated and pictures were taken at 3 days post-amputation (dpa). In each replicated experiment approximately 80% of the cripto-1morphants were resistant to inhibition of regeneration by BDP exposure.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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