FIGURE

Fig. 3

ID

ZDB-FIG-190620-26

Publication

Cau et al., 2019 - A Notch-mediated, temporal asymmetry in BMP pathway activation promotes photoreceptor subtype diversification

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Fig. 3

Impairing Notch activity modifies the timing of PhR differentiation and favors early PhR fate at the expense of late PhR fate.

(A-B) Representative confocal sections showing the expression of the Tg(aanat2:gfp)^y8(aanat2:gfp) transgene in Tg(hsp70l:dnXla.Rbpj-MYC)^vu21 (referred to as Notch KD) and wt siblings at 42 hpf. (C-F) Expression of exorh and PT in Tg(hsp70l:dnXla.Rbpj-MYC)^vu21 and siblings at 48 hpf (C-D) and 66 hpf (E-F). (G) Counts of Tg(aanat2:gfp)^y8+ cells at various stages in Tg(hsp70l:dnXla.Rbpj-MYC)^vu21 and siblings. The stage is indicated on the x-axis. (H) Counts of exorh+ and PT+ cells in Tg(hsp70l:dnXla.Rbpj-MYC)^vu21 and sibling embryos after in situ hybridization. Stages are 48 hpf for exorh+ and 66 hpf for PT+ cells. Scale bars represents 10 μm. Heat shock was performed at 14 hpf. Error bars represent SD. *p < 0.05, **p < 0.001 using a Mann Whitney test. Underlying data can be found in S1 Data. exorh, exorhodopsin; hpf, hours post fertilization; KD, knock-down; PhR, photoreceptor; PT, parietopsin; wt, wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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