FIGURE

Fig. 5

ID

ZDB-FIG-190523-5

Publication

Lalonde et al., 2018 - Contributions of 5'HoxA/D regulation to actinodin evolution and the fin-to-limb transition

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Fig. 5

The “m-Inta11” and “2PΔEpi” enhancer elements display overlapping domains of activity in the zebrafish pectoral fin fold mesenchyme at 72hpf. (A-D) Zebrafish pectoral fin at 72hpf of Tg(2PΔEpi:mCherry) x Tg(m-Inta11:eGFP) double transgenic fish. Both regulatory elements drive overlapping reporter expression in posterior fin fold mesenchyme (yellow arrow) (B-D), providing evidence they may both be co-activated by Hoxa13a and Hoxd13a proteins. Note the absence of reporter activity in anterior fin fold mesenchyme (B-D). Due to inconsistencies within transgenic lines, individual cells contain variable amounts of eGFP and mCherry protein and accounts for the colour variation observed in different mesenchymal cells (D). Brightfield (A), Fluorescent (B, C), and merged (D) images are displayed. ED, endoskeletal disc; FF, fin fold. Scale bar, 3 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Dev. Biol.