FIGURE

Fig. 2

ID

ZDB-FIG-180827-70

Publication

Daane et al., 2018 - Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Kcnk5b mediates the effect of calcineurin in regulating proportion. (A) Example of growth of pectoral fins of wildtype or kcnk5b deletion mutants regenerating after treatment with FK506. Dashed line indicates plane of section; black bar extent of growth of untreated fin; red, resected fin. (B) Growth rates of wildtype and kcnk5b deficient zebrafish. Dashed line, size of original pre-cut fin. Error bars represent ± SEM. ANOVA genotype by treatment interaction F(1,45) = 6.59, p = 0.014. Pairwise comparisons (ANOVA p-value): kcnk5b^−/− FK506-wt FK506 (0.0013), kcnk5b^−/− DMSO-wt DMSO (1.0), kcnk5b^−/− FK506-kcnk5b^−/− DMSO (0.022). (C) Growth rate of regenerating fins of different kcnk5b genotypes treated with FK506. Gray dots represent individual fish. Two-tailed t-test p < 0.0002 for suppression of growth in the absence of kcnk5b. Data is from four independent experiments. (C) Representative ventral view of pectoral fins after regeneration.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	slc45a2^{unspecified/unspecified} kcnk5b^{j131x8/j131x8}; slc45a2^{unspecified/unspecified}
Condition:	amputation: pectoral fin, chemical treatment by environment: tacrolimus (anhydrous)
Observed In:	pectoral fin regenerating fin regenerating fin growth
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.