FIGURE

Fig. 7

ID

ZDB-FIG-180420-58

Publication

Raghupathy et al., 2017 - Rpgrip1 is required for rod outer segment development and ciliary protein trafficking in zebrafish

Other Figures

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Fig. 7

Impairment of visual function in rpgrip1 ^−/− zebrafish. (A) Representative ERG traces from wildtype and rpgrip1 ^−/− zebrafish at 7dpf. D-wave was absent in the mutant zebrafish. (B) b-wave amplitudes of rpgrip1 ^−/− zebrafish (n = 10) were significantly reduced when compared to wildtype siblings (n = 11). The result is shown as mean ± SD. SD: standard deviation. **p < 0.01. (C) Visual background adaption for wildtype (n = 10) and rpgrip1 ^−/− zebrafish (n = 10) at 7dpf responding to dark adaption and bright light stimulation. Representative images showing that melanin of wildtype zebrafish was aggregated into small granules after light adaption, while rpgrip1 ^−/− zebrafish displayed larger diffused melanin granules.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rpgrip1^fh314/fh314
Observed In:	detection of light stimulus involved in visual perception melanocyte melanosome
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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