FIGURE

Fig. 1

ID

ZDB-FIG-180117-13

Publication

Pena et al., 2017 - Pyridoxine-Dependent Epilepsy in Zebrafish Caused by Aldh7a1 Deficiency

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Fig. 1

Pipecolic acid (left) and saccharopine (right) pathways for L-lysine catabolism in animals. The L-pipecolic acid pathway. LKR (lysine-ketoglutarate reductase) domain and SDH (saccharopine dehydrogenase) domain of the bifunctional AASS (aminoadipic semialdehyde synthase) enzyme. Antiquitin (encoded by the gene ALDH7A1) is deficient in pyridoxine-dependent epilepsy (red) leading to accumulation of AASA and P6C (red arrows). PIPOX (pipecolic acid oxidase). P5CR (piperideine-5-carboxilic reductase), encoded by the gene PYCR1. Further enzymatic steps convert AAA to Acetyl-CoA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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