ZFIN Figure: Ogryzko et al., 2014, Fig. 4

ZFIN ID: ZDB-FIG-170807-47

ZFIN ID: ZDB-FIG-170807-47

Ogryzko et al., 2014 - Zebrafish tissue injury causes up-regulation of interleukin-1 and caspase dependent amplification of the inflammatory response. Disease models & mechanisms 7(2):259-64 Full text @ Dis. Model. Mech.

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Genes:	cxcl8a il1b ptgs2b
Fish:	i114Tg s1999tTg; sh256Tg
Conditions:	chemical treatment by environment: purinergic receptor P2X antagonist, transection: caudal fin transection: caudal fin chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor, transection: caudal fin
Anatomical Term:	leukocyte
Stage:	Protruding-mouth

PHENOTYPE:

Fish:	i114Tg s1999tTg; sh256Tg
Conditions:	chemical treatment by environment: purinergic receptor P2X antagonist, transection: caudal fin transection: caudal fin chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor, transection: caudal fin
Observed In:	leukocyte
Stage:	Protruding-mouth

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
cxcl8a	i114Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte	RTPCR
	i114Tg	transection: caudal fin	Protruding-mouth	leukocyte	RTPCR
	i114Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte	RTPCR
il1b	i114Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte	RTPCR
	i114Tg	transection: caudal fin	Protruding-mouth	leukocyte	RTPCR
	i114Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte	RTPCR
ptgs2b	i114Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte	RTPCR
	i114Tg	transection: caudal fin	Protruding-mouth	leukocyte	RTPCR
	i114Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin	Protruding-mouth	leukocyte	RTPCR
	s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte	RTPCR

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
i114Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte cxcl8a expression increased amount, abnormal
		Protruding-mouth	leukocyte il1b expression amount, ameliorated
		Protruding-mouth	leukocyte ptgs2b expression increased amount, abnormal
i114Tg	transection: caudal fin	Protruding-mouth	leukocyte cxcl8a expression increased amount, abnormal
		Protruding-mouth	leukocyte il1b expression increased amount, abnormal
		Protruding-mouth	leukocyte ptgs2b expression increased amount, abnormal
i114Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte cxcl8a expression increased amount, abnormal
		Protruding-mouth	leukocyte il1b expression amount, ameliorated
		Protruding-mouth	leukocyte ptgs2b expression increased amount, abnormal
s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: purinergic receptor P2X antagonist	Protruding-mouth	leukocyte cxcl8a expression increased amount, abnormal
		Protruding-mouth	leukocyte il1b expression amount, ameliorated
		Protruding-mouth	leukocyte ptgs2b expression increased amount, abnormal
s1999tTg; sh256Tg	transection: caudal fin	Protruding-mouth	leukocyte cxcl8a expression increased amount, abnormal
		Protruding-mouth	leukocyte il1b expression increased amount, abnormal
		Protruding-mouth	leukocyte ptgs2b expression increased amount, abnormal
s1999tTg; sh256Tg	transection: caudal fin, chemical treatment by environment: EC 3.4.22.36 (caspase-1) inhibitor	Protruding-mouth	leukocyte cxcl8a expression increased amount, abnormal
		Protruding-mouth	leukocyte il1b expression amount, ameliorated
		Protruding-mouth	leukocyte ptgs2b expression increased amount, abnormal

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.