ZFIN is now using GRCz12tu for Genomic Data
Gene
cxcl8a
- ID
- ZDB-GENE-081104-317
- Name
- chemokine (C-X-C motif) ligand 8a
- Symbol
- cxcl8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables chemokine activity. Acts upstream of or within several processes, including blood vessel morphogenesis; endothelial to hematopoietic transition; and hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including eye; heart; liver; pleuroperitoneal region; and ventral wall of dorsal aorta. Used to study vitamin D-dependent rickets. Human ortholog(s) of this gene implicated in several diseases, including acute pyelonephritis; autoimmune uveitis; gastritis (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human CXCL8 (C-X-C motif chemokine ligand 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 91 figures from 66 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cxcl8a | El-Sammak et al., 2022 | |
| CRISPR2-cxcl8a | Yang et al., 2022 | |
| CRISPR3-cxcl8a | Yang et al., 2022 | |
| CRISPR4-cxcl8a | Lu et al., 2023 | |
| CRISPR5-cxcl8a | Lu et al., 2023 | |
| CRISPR6-cxcl8a | Lu et al., 2023 | |
| MO1-cxcl8a | N/A | (4) |
| MO2-cxcl8a | N/A | Stoll et al., 2011 |
| MO3-cxcl8a | N/A | (2) |
| MO4-cxcl8a | N/A | (4) |
1 - 10 of 13
Show
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| vitamin D-dependent rickets | cxcl8auwm25/uwm25 | standard conditions | Cortes et al., 2016 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chemokine beta/gamma/delta | Chemokine interleukin-8-like domain | Chemokine interleukin-8-like superfamily | CXC chemokine | CXC Chemokine domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0G2KYH9 | InterPro | ||||||
| UniProtKB:A0A8M3B7M3 | InterPro | 97 |
1 - 2 of 2
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cxcl8a-201
(1)
|
Ensembl | 716 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(runx1:cxcl8a-2A-mCherry) |
| 1 | Binder et al., 2023 |
1 - 1 of 1
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-151B16 | ZFIN Curated Data |
1 - 1 of 1
Show
- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001342570 (1) | GRCz12tu | 626 nt | |
| Genomic | GenBank:CT826376 (1) | 164364 nt | ||
| Polypeptide | UniProtKB:A0A8M3B7M3 (1) | 97 aa |
- Deng, D., Zhao, B., Yang, H., Wang, S., Geng, Z., Zhou, J., Yang, G., Han, L. (2025) Investigating the Effect and Potential Mechanism of Rhamnetin 3-O-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro. Pharmaceuticals (Basel, Switzerland). 18:
- Deng, L., Feng, Z., Li, X., Fan, L., Wu, X., Tavakoli, S., Zhu, Y., Ye, H., Wu, K. (2025) Exploring the potential mechanism of B-phycoerythrin on DSS-induced colitis and colitis-associated bone loss based on network pharmacology, molecular docking, and experimental validation. Scientific Reports. 15:54555455
- Fargher, E., Keatinge, M., Pearce, O., Piepponen, P., Panula, P., van Eeden, F.J.M., MacDonald, R.B., Bandmann, O. (2025) A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson's disease. NPJ Parkinson's disease. 11:118118
- Gomes, M.C., Brokatzky, D., Mostowy, S. (2025) Shigella-trained pro-inflammatory macrophages protect zebrafish from secondary infection. Cell Reports. 44:115601115601
- Leon-Icaza, S.A., Frétaud, M., Cornélie, S., Bureau, C., Yatime, L., Floto, R.A., Renshaw, S.A., Herrmann, J.L., Langevin, C., Cougoule, C., Bernut, A. (2025) Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 186:117957117957
- Liu, L., Hu, W., Kerman, F.D., Spaink, H.P. (2025) Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae. International journal of biological sciences. 21:823841823-841
- Martínez-López, A., Tyrkalska, S.D., Martínez-Morcillo, F.J., Abenza-Olmos, C., Lozano-Gil, J.M., Candel, S., Mulero, V., García-Moreno, D. (2025) SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish. Frontiers in immunology. 16:15097251509725
- Qin, L., Hu, C., Zhao, Q., Wang, Y., Fan, D., Lin, A., Xiang, L., Chen, Y., Shao, J. (2025) Unraveling the role of Ctla-4 in intestinal immune homeostasis through a novel Zebrafish model of inflammatory bowel disease. eLIFE. 13:
- Ye, J., Lu, L., Rui, X.H., Ren, M.D., Tu, F., Shang, Z.B., Liu, J. (2025) Zebrafish as a model for investigating Klebsiella pneumoniae-driven lung injury and therapeutic targets. Experimental Lung Research. 51:112211-22
- Arroyo, A.B., Tyrkalska, S.D., Bastida-Martínez, E., Monera-Girona, A.J., Cantón-Sandoval, J., Bernal-Carrión, M., García-Moreno, D., Elías-Arnanz, M., Mulero, V. (2024) Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation. Cell death discovery. 10:388388
1 - 10 of 345
Show