FIGURE

Fig. S6

ID

ZDB-FIG-170523-28

Publication

Lopez et al., 2017 - A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

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Fig. S6

Dendra-tau aggregation in transgenic zebrafish Further data supporting tau aggregation shown in main Fig.4. (A) Thioflavin-S staining of transverse sections through the eye and brain at the level of the optic chiasm. Positive staining was observed in both WT- and A152T-tau fish indicating tau aggregation and the presence of NFTs with increased accumulation in fish expressing the mutant A152T-tau (arrowheads). Upper panel, DAPI (nuclear) stained sections of eye and brain with selected regions stained with thioflavin-S presented at higher magnification below (i-iv show eye; i'-iv' brain). Scale bar represents 40 μm. Scale bar represents 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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