FIGURE

Fig. S5

ID

ZDB-FIG-160826-21

Publication

Ji et al., 2016 - Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs

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Fig. S5

Pitx2HD mutants develop eye and tooth defects associated with ARS. (A) Cryosections of the eye from 5 dpf wild-type (+/+) or pitx2HD^sny6/sny6 (-/-) fish stained with crystal violet. AC=anterior chamber; ICA=iridocorneal angle. Scale bars=50 µm. Box1 and Box2 are zoom-in views of boxed structures. Retina organization appeared similar in wild-type and pitx2HD mutant fish. (B) Ventral views of alizarin red staining of teeth at 5 dpf wild-type, pitx2HD^sny6/sny6 and pitx2HD^sny15/sny15 fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pitx2^sny6/sny6 (AB/TU)
Observed In:	anterior segment eye aqueous humor camera-type eye morphogenesis ceratobranchial 5 cartilage ceratobranchial 5 primary tooth cornea iris odontogenesis tooth 3V tooth 4V tooth 5V (all 11)
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.