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Fig. 2

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ZDB-FIG-160401-8

Publication

Ott et al., 2016 - Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm

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Fig. 2

Mnx2b knock down causes proximal pronephric tubule dilation and excretion defects. (A, B) Lateral views of 4dpf Tg(cldnb:lynGFP) control (A) and mnx1/mnx2b morpholino injected embryos (single plane confocal image, proximal tubule is indicated by white arrowheads). (C-F) Dorsal views of proximal tubule segments (C, D) as well as proximal to distal transition domains (E, F) in 2dpf Tg(cldnb:lynGFP) control (I, J) and morpholino injected embryos. (G) Tubule width in control, single and combined morpholino injected embryos at 4dpf. (H, I) Excretion of rhodamine dextran after injection into the common cardinal vein in controls (H, H′) and mnx-morphant (I, I′) Tg(cldnb:lynEGFP) embryos at 3dpf (lateral view, white arrows indicate position of duct lumen). 92% of controls showed excretion 5min after injection, compared to only 35% of Mo-mnx injected embryos (P).

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Antibody Labeling

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Acknowledgments

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Reprinted from Developmental Biology, 411(1), Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D., Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm, 101-14, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.