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Fig. 7

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ZDB-FIG-160401-13

Publication

Ott et al., 2016 - Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm

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Fig. 7

Knockdown of irx1b in mnx morphants partially rescues pronephric phenotypes. Shown is a lateral view of Acetylated tubulin stained Tg(cldnb:lynEGFP) embryos that were injected with Mo-mnx alone (A, A′) or in combination with Mo-irx1b (B, B′). Measurement of tubule widths shows partial rescue of the MO-mnx phenotype in the combination mnx/irx1b double knockdown (C). Excretory defects in Mo-mnx injected embryos are rescued by additional irx1b knockdown (D). TEM sections of embryos co-injected for mnx and irx1b morpholinos demonstrate reduced pronephric tubule width and restored morphology of microvilli (E, E′; Scale bars correspond to 5 and 2 µm, respectively).

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Acknowledgments

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Reprinted from Developmental Biology, 411(1), Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D., Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm, 101-14, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.