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Fig. 5

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ZDB-FIG-160401-11

Publication

Ott et al., 2016 - Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm

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Fig. 5

Direct transcriptional repression of irx1b through Mnx factors. Outline of the transplantation experiment. Mnx1VP16 embryos are injected with fluorescein dextran at the 1-cell stage. Fluorescein positive cells are transplanted into wt embryos during shield stage. Embryos are fixed 2h after 1h inductive heat-activation and analysed for fluorescein and irx1b expression (A). Transplanted transgenic cells ectopically express irx1b (B, B′). Lateral view of irx1b stained wt embryos is shown (C) and after CHX treatment (D). Irx1b expression is similarly induced in mnx1-VP16 expressing embryos (E, F), and similarly reduced in mnx1 overexpressing embryos (G, H) without or with CHX, respectively.

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Acknowledgments

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Reprinted from Developmental Biology, 411(1), Ott, E., Wendik, B., Srivastava, M., Pacho, F., Töchterle, S., Salvenmoser, W., Meyer, D., Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm, 101-14, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.