FIGURE

Fig. 1

ID

ZDB-FIG-150915-54

Publication

Gao et al., 2015 - TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis

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Fig. 1

The definitive hematopoiesis is defective in zebrafish mutant^cas003 embryos.

(A, A′) The bright field images of zebrafish wild-type sibling (A) and mutant^cas003 embryos (A′) showing no obvious difference at 5dpf. (B-G′) Whole-mount in situ hybridization (WISH) results of c-myb, ae1-globin, mpx, lyz and rag1 showing defective definitive hematopoiesis in mutant^cas003 embryos (B′-G′) but not in sibling embryos (B-G) at 5dpf. The penetrance of the indicated phenotype is shown in the bottom left of each panel. (B-F, B′-F′) Lateral views; (G, G′) dorsal views. Black arrows indicate the position of caudal hematopoietic tissue (CHT); red arrows and circles show the position of thymus and kidney, respectively.

Expression Data

Genes:	hbae1.1 lyz mpx myb rag1
Fish:	WT topbp1^{cas003/cas003}
Anatomical Terms:	granulocyte hematopoietic system granulocyte hematopoietic system nucleate erythrocyte hematopoietic system posterior side kidney kidney granulocyte kidney macrophage macrophage nucleate erythrocyte thymus thymus lymphocyte
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	topbp1^{cas003/cas003}
Observed In:	definitive hemopoiesis
Stage:	Day 5

Phenotype Detail

Acknowledgments

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