Gene

hbae1.1

ID

ZDB-GENE-980526-80

Name

hemoglobin, alpha embryonic 1.1

Symbol

hbae1.1 Nomenclature History

Previous Names

ae1a (1)
hba2
HBA2r
HbA (1)
HBAA1 (1)
hbae1
hbae1a (1)
alphae1globin (1)
etID40432.3 (1)
globin alphae1 (1)
si:by119c3.1
si:by119c3.3
si:xx-119c3.3
wu:fa12a11
wu:fb74f06 (1)
zgc:86936 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to be involved in oxygen transport. Predicted to localize to hemoglobin complex. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Is expressed in several structures, including hematopoietic cell; hematopoietic system; mesoderm; presumptive blood; and renal system. Orthologous to human HBA1 (hemoglobin subunit alpha 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

121 figures from 79 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hbae1.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
alpha thalassemia	Alliance	Thalassemias, alpha-	604131
familial erythrocytosis 7	Alliance	Erythrocytosis, familial, 7	617981
Heinz body anemia	Alliance	Heinz body anemias, alpha-	140700
hemoglobin H disease	Alliance	Hemoglobin H disease, nondeletional	613978
		Methemoglobinemia, alpha type	617973

Associated With hbae1.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000971	Globin
Family	IPR002338	Hemoglobin, alpha-type
Family	IPR002339	Hemoglobin, pi
Homologous_superfamily	IPR009050	Globin-like superfamily
Homologous_superfamily	IPR012292	Globin/Protoglobin

Domain Details Per Protein

Protein	Length	Globin	Globin-like superfamily	Globin/Protoglobin	Hemoglobin, alpha-type	Hemoglobin, pi
UniProtKB:Q7ZT21 InterPro	143

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hbae1-001 (1)	Havana	877 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hbae1.1-201 (1) Ensembl	Havana	633 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000002407 (1)	Havana	555 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ottdart00000002419 (1)	Havana	838 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations