FIGURE

Fig. 2

ID

ZDB-FIG-150313-28

Publication

Huc-Brandt et al., 2014 - Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development

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Fig. 2

PrP2 is involved in PLL development.

A, C. Alkaline phosphatase staining of the trunk neuromasts (arrows) in wild type embryos at 72 hpf. C. High magnification of boxed area in A. B, D. In Prp2^/ mutant, less neuromasts are visible with the first neuromast displaced anteriorly (B, white arrow) D. High magnification of boxed area in B. E–G. In Control (E), PrP2-MO/p53-MO (F) and PrP2-MO (G), the total neuromast number is decreased in morphants. H. Quantification of total neuromast number shows a significant decrease in morphants and mutants compared to control. I. Neuromast position along the somite axis, scheme adapted from [28]. In Prp2^/ mutant, L1 is retrieved anteriorly to the normal L1 position while in morphants, the present neuromasts are displaced posteriorly. *: p<0.05, ***: p<0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	prnprs3^{ua5001/ua5001} (AB) WT + MO4-tp53 + MO5-prnprs3 WT + MO5-prnprs3
Knockdown Reagents:	MO4-tp53 MO5-prnprs3
Observed In:	posterior lateral line posterior lateral line development posterior lateral line neuromast
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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