FIGURE

Fig. 4

ID

ZDB-FIG-140811-40

Publication

Zhu et al., 2014 - Haploinsufficiency of Def Activates p53-Dependent TGFbeta Signalling and Causes Scar Formation after Partial Hepatectomy

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Fig. 4

Def haploinsufficiency results in accumulation of ColI at the amputation site after PH.

(A,B) Representative images of immunostaining of keratin 18 (green) (A) and co-immunostaining of ColI (red) and Bhmt (green) (B) at the amputation site in wild-type and def^+/- strains 3 days after PH. Nuclei were stained with DAPI (blue). At each time-point, more than 10 sections from at least three wild-type or def^+/- mutant fish were examined. lv, liver tissue; we, wound epidermis. Scale bars: 75 μm (A,B) and 100 μm (C).

Expression Data

Antibodies:	Ab1-bhmt Ab2-col1a1 Ab3-krt18
Fish:	WT utp25^hi429Tg/+
Condition:	physical alteration: anatomical structure
Anatomical Terms:	hepatocyte liver regenerating tissue
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	utp25^hi429Tg/+
Condition:	physical alteration: anatomical structure
Observed In:	liver connective tissue replacement involved in inflammatory response wound healing
Stage:	Adult

Phenotype Detail

Acknowledgments

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