ZFIN ID: ZDB-FIG-130814-11
Reimer et al., 2013 - Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration. Developmental Cell   25(5):478-491 Full text @ Dev. Cell
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Condition:
Anatomical Term:
Stage: Days 7-13

Fig. 6 Early Disruption of Dopamine Signaling Has Long-Lasting Consequences for Motor Neuron Numbers and Swimming Behavior (A) Motor neuron numbers (lateral trunk views) are significantly reduced at 9 dpf by exposure to 10 μM L-745870 from 24 to 72 hpf (Kruskal-Wallis p = 0.0102 with Dunn’s multiple comparison, p < 0.05, p < 0.0001). Scale bar, 25 μm. (B and C) Incubation of embryos from 1 to 3 dpf decreases (B) the frequency of a startle response after touch at 4 dpf and (C) the total distance moved and high mobility frequency at 9 dpl (p < 0.01; p < 0.0001). Error bars represent SEM. See also Figure S5.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP ml2Tg control Days 7-13 spinal cord motor neuron IFL
ml2Tg chemical treatment: drug Days 7-13 spinal cord motor neuron IFL
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
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Reprinted from Developmental Cell, 25(5), Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G., Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration, 478-491, Copyright (2013) with permission from Elsevier. Full text @ Dev. Cell