FIGURE
Fig. 2
- ID
- ZDB-FIG-120216-14
- Publication
- Parker et al., 2011 - Ancient Pbx-Hox Signatures Define Hundreds of Vertebrate Developmental Enhancers
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Fig. 2
CNE 3299 harbours essential conserved Pbx-Hox and Meis binding-sites. A, multiple sequence alignment of a region of CNE 3299 from human, zebrafish and lamprey highlighting conserved Pbx-Hox (blue box) and Meis (green box) binding-site motifs. The specific sites mutated in elements sub1 and sub2 are indicated below the alignment. B-C, compared to wild-type 3299 expression (B), mutating the first Pbx-Hox and Meis motif cluster (sub1) results in the loss of reporter expression in the neural crest (arrow) and broader expression in the hindbrain (arrowhead) (C). nc: neural crest. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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