Image
|
Figure Caption
Fig. 2
CNE 3299 harbours essential conserved Pbx-Hox and Meis binding-sites. A, multiple sequence alignment of a region of CNE 3299 from human, zebrafish and lamprey highlighting conserved Pbx-Hox (blue box) and Meis (green box) binding-site motifs. The specific sites mutated in elements sub1 and sub2 are indicated below the alignment. B-C, compared to wild-type 3299 expression (B), mutating the first Pbx-Hox and Meis motif cluster (sub1) results in the loss of reporter expression in the neural crest (arrow) and broader expression in the hindbrain (arrowhead) (C). nc: neural crest.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ BMC Genomics