ZFIN ID: ZDB-FIG-120206-10
Wiweger et al., 2012 - HSPG-Deficient Zebrafish Uncovers Dental Aspect of Multiple Osteochondromas. PLoS One   7(1):e29734 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 6

Fig. 4

Tooth phenotype in zebrafish mutants affected in FGF, IHH and PKC pathways.

Pharyngeal arch together with teeth from 6-days-old WT and dackel (dak/ext2), detour (dtr/gli1), heart and soul (has/prkci), pinscher (pic/slc35b2) and you too (yot/gli2a) homozygote mutants were stained with alizarin red, dissected and flat mounted. The average length of the 5th arch in WT larvae is 150 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ext2to273b/to273b standard conditions Day 6 ceratobranchial 5 bone decreased length, abnormal
Day 6 ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal
Day 6 ceratobranchial 5 tooth decreased length, abnormal
Day 6 ceratobranchial 5 tooth increased thickness, abnormal
extl3tw24/tw24 standard conditions Day 6 ceratobranchial 5 bone decreased length, abnormal
Day 6 ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal
Day 6 tooth mineralization delayed, abnormal
gli1tm276b/tm276b standard conditions Day 6 ceratobranchial 5 bone decreased length, abnormal
Day 6 ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal
gli2aty119/ty119 standard conditions Day 6 ceratobranchial 5 bone decreased length, abnormal
Day 6 ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal
Day 6 ceratobranchial 5 tooth decreased length, abnormal
Day 6 ceratobranchial 5 tooth increased width, abnormal
prkcim129/m129 standard conditions Day 6 ceratobranchial 5 bone decreased length, abnormal
Day 6 ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal
slc35b2to14mx/to14mx standard conditions Day 6 ceratobranchial 5 bone decreased length, abnormal
Day 6 ceratobranchial 5 bone has fewer parts of type ceratobranchial 5 tooth, abnormal
Day 6 ossification delayed, abnormal
Day 6 tooth mineralization delayed, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One