FIGURE

Fig. 4

ID

ZDB-FIG-120202-22

Publication

Ni et al., 2011 - Discovering Small Molecules that Promote Cardiomyocyte Generation by Modulating Wnt Signaling

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Fig. 4

Cardionogen Promotes Expansion of the Cardiac Progenitor Cell Population Expression of nkx2.5 (A and B), cmlc2 (C and D), vmhc (E and F), nkx2.5 (G and H), scl (I and J), insulin (K and L), and myoD (M and N) in CDNG1-treated and control embryos was examined using in situ hybridization. Expression of nkx2.5 [39 of 43 embryos in (A) and (B)], cmlc2 [42 of 47 embryos in (C) and (D)], vmhc [41 of 45 embryos in (E) and (F)], and nkx2.5 [38 of 41 embryos in (G) and (H)] is increased. Expression of scl (41 of 43 embryos), insulin (42 of 45 embryos), and myoD (39 of 42 embryos) is not altered. Images were taken at 12 hpf (A, B, I, and J), 17 hpf (C–F), 24 hpf (G, H, M, and N), and 48 hpf (K and L). Dorsal (A–F and I–L) and lateral views (G, H, M, and N) are shown. CTL, control; black arrow, heart tube. CDNG1, 30 μM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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