ZFIN Image: Ni et al., 2011, Fig. 4

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Figure Caption

Fig. 4

Cardionogen Promotes Expansion of the Cardiac Progenitor Cell Population Expression of nkx2.5 (A and B), cmlc2 (C and D), vmhc (E and F), nkx2.5 (G and H), scl (I and J), insulin (K and L), and myoD (M and N) in CDNG1-treated and control embryos was examined using in situ hybridization. Expression of nkx2.5 [39 of 43 embryos in (A) and (B)], cmlc2 [42 of 47 embryos in (C) and (D)], vmhc [41 of 45 embryos in (E) and (F)], and nkx2.5 [38 of 41 embryos in (G) and (H)] is increased. Expression of scl (41 of 43 embryos), insulin (42 of 45 embryos), and myoD (39 of 42 embryos) is not altered. Images were taken at 12 hpf (A, B, I, and J), 17 hpf (C–F), 24 hpf (G, H, M, and N), and 48 hpf (K and L). Dorsal (A–F and I–L) and lateral views (G, H, M, and N) are shown. CTL, control; black arrow, heart tube. CDNG1, 30 μM.

Acknowledgments

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