FIGURE

Fig. 7

ID

ZDB-FIG-120202-25

Publication

Ni et al., 2011 - Discovering Small Molecules that Promote Cardiomyocyte Generation by Modulating Wnt Signaling

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Fig. 7

Cardionogen Rescues Wnt8-Induced Cardiac Phenotypes (A–C) cmlc2 expression in non-heat-shocked embryos (A), heat-shocked embryos (B), and CDNG1-treated heat-shocked embryos (C). Of 25 embryos, 23 were rescued. (D–F) Rescue of heart formation labeled by cmlc2 expression in CDNG1-treated heat-shocked embryos (F) compared to heat-shocked embryos (E) and non-heat-shocked embryos (D). Of 26 embryos, 25 were rescued. (G–I) Inhibition of cardiac expansion labeled by cmlc2 expression in CDNG1-treated heat-shocked embryos (I), compared to heat-shocked embryos (H) and non-heat-shocked embryos (G). Of 24 embryos, 21 were inhibited. Heat shock was administered at 38.5°C for 15 min at 3 hpf (H and I) and 9 hpf (B, C, E, and F). Black arrow, cardiomyocytes; red arrow, ventricle; blue arrow, atrium.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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