FIGURE

Fig. 1

ID
ZDB-FIG-120201-11
Publication
Dworkin et al., 2012 - Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways
Other Figures
(all 13)
All Figure Page
Back to All Figure Page
Fig. 1

Loss of function of grhl2b leads to severe defects in the MHB region. (A,B) Embryos injected with control or grhl2b ATG-blocking MO. Lateral views with dorsal views in the insets. MB, midbrain; HB, hindbrain; apoptosis and folding defects are indicated by arrows and arrowheads. (C,D) Apoptosis is increased in grhl2b morphants (MO:grhl2b) compared with controls. (E-H) Positioning of either the midbrain (otx2) or hindbrain (gbx1) territories within the neural plate in grhl2b morphants compared with controls. (I-L) Expression of eng2a in grhl2b morphants and controls from the onset of MHB formation. (M-V) Expression of MHB patterning genes (eng2a, her5, wnt1 and pax2a) at 26 hpf in grhl2b morphants and controls. mhb, midbrain-hindbrain boundary; os, optic stalk; ov, otic vesicles.

Expression Data
Genes: (all 6)
Fish:
Knockdown Reagent:
Anatomical Terms:
Stage Range: Shield to Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In: (all 6)
Stage Range: 1-cell to Prim-5

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.