Gene
her5
- ID
- ZDB-GENE-990415-90
- Name
- hairy-related 5
- Symbol
- her5 Nomenclature History
- Previous Names
-
- zgc:136537
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including endoderm development; nervous system development; and positive regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Is expressed in several structures, including EVL; brain; endoderm; neural plate; and presumptive structure. Orthologous to human HES7 (hes family bHLH transcription factor 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 48 figures from 34 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu359 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Shin et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 4 | Alliance | Spondylocostal dysostosis 4, autosomal recessive | 613686 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Orange domain | Transcription factor HES-7, basic helix-loop-helix-orange domain |
|---|---|---|---|---|---|
|
UniProtKB:Q90467
|
205 |
Interactions and Pathways
No data available
Plasmids