FIGURE

Fig. 5

ID

ZDB-FIG-111026-5

Publication

Smith et al., 2011 - Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Bmp via Bmpr1a regulates lefty1 expression in the midline.

(A) In situ hybridisation for lefty1 at 15-somites on embryos from an incross of bmpr1aa+/-;bmpr1ab+/- double carrier fish. Embryos were analysed for lefty1 expression and classified as robust (blue boxed panel) or reduced (red boxed panel) expression after which the embryos were genotyped. Quantification of the results is shown in the stacked area graph (blue, robust lefty1; red reduced lefty1). (B) In situ hybridisation for lefty1 at 10-somite stage. Embryos shown are Tg(hsp70l:bmp2b) embryos either heat-shocked at 10 hpf to induce bmp2b expression (left panel) or without heat-shock (middle panel) and Tg(hsp70l:nog3) embryos heat-shocked at 10 hpf to inhibit Bmp signalling (right panel). Lateral view of 10-somite stage embryos with dorsal to the right and anterior up.

Expression Data

Gene:	lft1
Fish:	fr13Tg fr14Tg
Condition:	heat shock
Anatomical Terms:	head notochord notochord posterior region
Stage:	10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.