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Fig. 1

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ZDB-FIG-110720-60

Publication

Zhao et al., 2011 - A novel xenograft model in zebrafish for high-resolution investigating dynamics of neovascularization in tumors

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Fig. 1

The establishment of mammalian tumor xenograft models in zebrafish.

Red fluorescence-labeled malignant tumor cells (murine colon carcinoma CT26 and melanoma B16 cells) and non-tumorigenic HEK 293 cells were implanted into the abdominal perivitelline space (A, indicated by arrow) of 48 hpf Tg(flk1:EGFP) transgenic zebrafish embryos (50–100 cells/embryo). When tumors (B, red) reached 350–450 μm in diameter when filled with neo-vessels (B, green), the neoplasia were isolated and analyzed by H&E staining (B). The growth rate of xenografted tumors (C) and the number of tumor-induced neovessels (D) were analyzed quantitatively. * indicates the significant difference. Scale bar, 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

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