FIGURE

Fig. 2

ID

ZDB-FIG-101123-49

Publication

Gamba et al., 2010 - Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system

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Fig. 2

Migration of the PLL primordium is altered in esr1-MO embryos. (A) Three frames of a time-lapse movie of primordium migration in a cldnb:gfp embryo at 35 (t = 0), 38, and 41 hpf, respectively. At 41 hpf, the primordium has just migrated out of the field. (B) Five frames of a time-lapse movie of the primordium in an esr1-MO1 injected embryo at 35 (t = 0), 38, 41, 44, and 48 hpf, respectively. Migration is two to three times slower than in untreated cldnb:gfp embryos and eventually comes to a halt around 45 hpf. (C) In the same embryo, the immobile primordium has fragmented into two neuromasts at 51 hpf. (Scale bar in A: 50 μm.)

Expression Data

Gene:	EGFP
Fish:	ump1Tg; zf106Tg ump1Tg; zf106Tg + MO1-esr1
Knockdown Reagent:	MO1-esr1
Anatomical Term:	posterior lateral line primordium
Stage Range:	Prim-15 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ump1Tg; zf106Tg + MO1-esr1
Knockdown Reagent:	MO1-esr1
Observed In:	posterior lateral line neuromast primordium migration posterior lateral line primordium
Stage Range:	Prim-15 to High-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA