FIGURE

Fig. S5

ID

ZDB-FIG-101123-35

Publication

Knopf et al., 2010 - Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish

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Fig. S5

Combined treatment with Dox and Dex or with Dox and Tebufenozide is not toxic for adult zebrafish. (A) Average regenerate length at 8 d postamputation (dpa) of fish intraperitoneally injected with the indicated doses of drugs at 1 dpa, 3 dpa, and 6 dpa. Zero indicates EtOH vehicle only. Regenerate length is not significantly different (Student t test). Error bars indicate SEM. n = 6/group. (B and C) Representative regenerating fins at 7 dpa of fish housed in water containing vehicle or 25 μg/mL Dox plus 10 μM Tebufenozide. Note robust regeneration in both. Amputation plane is indicated by arrowheads. (D) Average regenerate length measured at 7 dpa of fish incubated with the indicated doses of drugs from 0.5 dpa. Zero indicates vehicle only. Regenerate length is not significantly different between vehicle control and drug-treated fins (Student t test). Error bars are SEM. n = 6/Group. (E) Average regenerate length at 8 dpa of fish intraperitoneally injected with the indicated doses of drugs at 1 dpa, 3 dpa, and 6 dpa. Zero indicates vehicle only. Regenerate length is not significantly different (Student t test). Error bars indicate SEM. n = 6/Group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA