FIGURE

Fig. 11

ID

ZDB-FIG-100616-122

Publication

Yao et al., 2010 - Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish

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Fig. 11

Skeletal muscle development is altered in Atoh8 knock-down embryos.

(A–H) myoD in situ hybridization; (I–L) myogenin in situ hybridization. (A–C) 9-Somite stage; (D–E) 15-Somite stage; (G–H) 36 hpf; (C,F,H,J and L) are controls and the remainder are morphants with (B) and (E) the severely affected embryos. Expression of the skeletal marker myoD in paraxial mesoderm showed to tendency towards a ventral localization (A,D) or the boundaries of the posterior somites were indistinct(B,C) and a U-shaped somite formation appeared in the morphant (G). Expression of the skeletal marker myogenin provides further evidence of abnormality (I–L).

Expression Data

Genes:	myod1 myog
Fish:	AB AB + MO1-atoh8 + MO5-tp53
Knockdown Reagents:	MO1-atoh8 MO5-tp53
Anatomical Terms:	paraxial mesoderm somite
Stage Range:	5-9 somites to Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-atoh8 + MO5-tp53
Knockdown Reagents:	MO1-atoh8 MO5-tp53
Observed In:	somite somite posterior-most region somite border somitogenesis
Stage Range:	14-19 somites to Prim-25

Phenotype Detail

Acknowledgments

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