ZFIN ID: ZDB-FIG-090817-53
Sun et al., 2009 - Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One   4(8):e6596 Full text @ PLoS One
Observed In:
Stage Range: Days 21-29 to Adult

Fig. 1 Chronic anemia induces cardiomegaly in tr265/tr265 zebrafish.

(A,A′) Pictures of the cardiomegaly in a week-16 (A′) tr265/tr265 and normal appearance of (A) a sibling; arrowhead points to the heart region. (B,B′) Dissected hearts of (B) the sibling and (B′) tr265/tr265; A, atrium, V, ventricle; bar = 1 mm. (C) Ventricle area to fish length (VA/BL) index used as a measurement of the cardiomegaly for week-4, -6, and -16 hearts. (D) Percent relative hemoglobin concentration at week 16. (E) Body length (in mm) at week 6 and 16. (F) Body mass (in grams) at week 6 and 16. (C–F) mean±SEM; * = P<0.05. n = number of fish examined.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
slc4a1atr265/tr265 standard conditions Days 21-29 heart increased size, abnormal
Days 21-29 nucleate erythrocyte decreased amount, abnormal
Days 30-44 heart increased size, abnormal
Adult atrium increased size, abnormal
Adult bulbus arteriosus increased size, abnormal
Adult cardiac ventricle increased size, abnormal
Adult heart increased size, abnormal
Adult nucleate erythrocyte hemoglobin complex decreased amount, abnormal
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One