FIGURE

Fig. 3

ID

ZDB-FIG-081103-28

Publication

Thomas et al., 2008 - Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential

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Fig. 3

Increased Hedgehog signaling expands cardiomyocyte numbers. (A-F) Dorsal views, anterior towards the top. Scale bars: 100 μm. (A-C) nkx2.5 expression at the seven-somite stage is subtly expanded in shh-injected and ptc1;ptc2 double mutant embryos. The observed extent of anterior-posterior enlargement was variable. (D-F) cmlc2 expression at the 18-somite stage is expanded in shh-injected and ptc1;ptc2 double mutant embryos. The degree of expansion was variable and frequently coupled with disorganized morphology of migrating cardiomyocyte populations, as in E.

Expression Data

Genes:	myl7 nkx2.5
Fish:	WT ptch1^tj222/tj222; ptch2^{hu1602/hu1602}
Anatomical Term:	heart primordium
Stage Range:	5-9 somites to 14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ptch1^tj222/tj222; ptch2^{hu1602/hu1602}
Observed In:	heart primordium cardiac muscle myoblast
Stage Range:	5-9 somites to 14-19 somites

Phenotype Detail

Acknowledgments

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