FIGURE

Fig. 4

ID
ZDB-FIG-071001-4
Publication
Latimer et al., 2006 - Notch signaling regulates midline cell specification and proliferation in zebrafish
Other Figures
All Figure Page
Back to All Figure Page
Fig. 4

Notch signaling limits notochord and promotes hypochord development during gastrulation. (A, B, G, H) Side views, anterior to the left, at 20 hpf (22-somite stage) and (C, D) dorsal views, animal pole at top, at 9.5 hpf (YPC stage) showing ntl-expressing notochord cells. (A) Control embryo showing normal pattern of ntl-expressing notochord at the midline. (B) Expression of NICD at 6 hpf reduced trunk notochord (arrows). (C) Normal pattern of notochord precursors at 9.5 hpf. (D) The number of notochord precursors was reduced (asterisk) in embryos after induction of NICD at 6 hpf. (E, F) her4 expression in hypochord precursors at 9.5 hpf, dorsal view. (E) her4 was expressed in a row on both sides of the midline (arrows) in control embryos. (F) her4 was expressed throughout the midline (asterisk) after expression of NICD at 6 hpf. (G) Control embryo showing normal pattern of tail ntl expression in the notochord. (H) Expression of NICD at 10 hpf reduced tail notochord (asterisk), but trunk notochord appeared normal (arrow). Scale bar: 40 μm for panels A, B, G, H; 80 μm for panels E, F.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 298(2), Latimer, A.J., and Appel, B., Notch signaling regulates midline cell specification and proliferation in zebrafish, 392-402, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.